PF3D7_0625700

Genome location: Pf3D7_06_v3:1,042,132..1,043,395(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0625700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.318 | MFS: -3.282 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1124600)

• Relative Growth Rate: 0.84 ± 0.12
• Confidence: 5.61

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1124600)

Modification: Disrupted | RMgm-3063

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT93

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139421

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 43

Non-coding: 40 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 98 | Molecular Weight (kDa): 12.007

UniProt ID(s): C6KT93

PDB ID(s): None

Isoelectric Point: 10.14

Protein Domain Annotations: