PF3D7_0625900

Genome location: Pf3D7_06_v3:1,046,986..1,048,052(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.04	0.98
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.10	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0625900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.177 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1124700)

Modification: Disrupted | RMgm-3064

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT95

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533558

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	15	8	23
disruptive	14	35	29	56
missense	14	34	29	54

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	27	13	33
disruptive	27	90	34	91
missense	22	81	32	75

PlasmoDB Total SNPs: 29

Non-coding: 10 | Synonymous: 6 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 326 | Molecular Weight (kDa): 38.532

UniProt ID(s): C6KT95

PDB ID(s): None

Isoelectric Point: 9.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A