PF3D7_0626000

Genome location: Pf3D7_06_v3:1,048,453..1,055,207(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.32	0.84
Trophozoite	expressed	0.52	0.70
Schizont	possibly expressed	0.29	0.82
Gametocyte	expressed	0.38	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0626000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.613 | MFS: -2.988 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT96

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.07) with 6JWV (Global RMSD=21.14)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532407

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	81	35	93
disruptive	65	192	106	259
missense	46	148	96	211

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	143	67	109
disruptive	121	390	208	468
missense	79	303	165	294

PlasmoDB Total SNPs: 330

Non-coding: 125 | Synonymous: 90 | Nonsynonymous: 115 | Stop Codon: 0

Protein Information

Protein Length: 1751 | Molecular Weight (kDa): 209.433

UniProt ID(s): C6KT96

PDB ID(s): None

Isoelectric Point: 7.62

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A