PF3D7_0626200

Genome location: Pf3D7_06_v3:1,058,496..1,060,180(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.26	0.87
Trophozoite	not expressed	0.31	0.81
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0626200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -3.161 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT98

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533496

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	13	12	31
disruptive	14	59	27	76
missense	9	50	26	68

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	33	23	24
disruptive	26	126	50	143
missense	16	104	37	94

PlasmoDB Total SNPs: 35

Non-coding: 11 | Synonymous: 8 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 418 | Molecular Weight (kDa): 50.371

UniProt ID(s): C6KT98

PDB ID(s): None

Isoelectric Point: 4.65

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A