PF3D7_0626400

Genome location: Pf3D7_06_v3:1,064,859..1,068,640(+)

Genome classification: Core

Function and Localization

Product Description: CRAL/TRIO domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	not expressed	0.46	0.73
Schizont	possibly expressed	0.70	0.60
Gametocyte	expressed	0.89	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0626400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.286 | MFS: -2.591 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1125200)

Relative Growth Rate: 0.06 ± 0.09
Confidence: 6.16

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTA0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111807

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	53	28	61
disruptive	26	139	60	185
missense	17	113	54	147

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	103	50	52
disruptive	72	295	145	321
missense	42	220	107	211

PlasmoDB Total SNPs: 132

Non-coding: 20 | Synonymous: 58 | Nonsynonymous: 54 | Stop Codon: 0

Protein Information

Protein Length: 1159 | Molecular Weight (kDa): 136.29

UniProt ID(s): C6KTA0

PDB ID(s): None

Isoelectric Point: 9.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001251	CRAL-TRIO lipid binding domain
InterPro	IPR036273	CRAL/TRIO, N-terminal domain superfamily
InterPro	IPR036865	CRAL-TRIO lipid binding domain superfamily
PFam	PF00650	CRAL-TRIO lipid binding domain
Superfamily	SSF46938	CRAL/TRIO, N-terminal domain superfamily
Superfamily	SSF52087	CRAL-TRIO lipid binding domain superfamily
Superfamily	SSF69349