PF3D7_0626500 (CEP135)

Genome location: Pf3D7_06_v3:1,069,962..1,072,805(+)

Genome classification: Core

Function and Localization

Product Description: centrosomal protein CEP135, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005856	cytoskeleton

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.04	0.98
Schizont	no data	0.05	0.97
Gametocyte	no data	0.42	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0626500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.529 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1125300)

Relative Growth Rate: 0.98 ± 0.13
Confidence: 5.42

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1125300)

Modification: Disrupted | RMgm-3068

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTA1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103263

Most Similar Human Ortholog: Q9H4Y4

TM-align score: 0.87 | RMSD: 1.42

Seq Identity: 0.10 | Length: 86 / 947

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000120051	cilia and flagella associated protein 58

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	41	32	49
disruptive	16	137	63	174
missense	15	116	51	125

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	85	31	62
disruptive	58	326	112	304
missense	36	235	72	164

PlasmoDB Total SNPs: 90

Non-coding: 0 | Synonymous: 41 | Nonsynonymous: 48 | Stop Codon: 1

Protein Information

Protein Length: 947 | Molecular Weight (kDa): 112.89

UniProt ID(s): C6KTA1

PDB ID(s): None

Isoelectric Point: 9.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF57997	N/A