Product Description: ATPase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0005524 | ATP binding |
| Function | GO:0016887 | ATP hydrolysis activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.19 | 0.90 |
| Trophozoite | no data | 0.31 | 0.81 |
| Schizont | no data | 0.05 | 0.97 |
| Gametocyte | no data | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0626700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.163 | MFS: -2.643 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTA3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102232
Most Similar Human Ortholog: F8VR84
TM-align score: 0.91 | RMSD: 1.66
Seq Identity: 0.39 | Length: 206 / 372
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000139637 | MYG1 exonuclease |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 16 | 10 | 23 |
| disruptive | 2 | 17 | 15 | 43 |
| missense | 2 | 17 | 15 | 39 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 33 | 14 | 32 |
| disruptive | 3 | 50 | 42 | 104 |
| missense | 2 | 45 | 33 | 62 |
PlasmoDB Total SNPs: 116
Non-coding: 101 | Synonymous: 10 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 372 | Molecular Weight (kDa): 43.65
UniProt ID(s): C6KTA3
PDB ID(s): None
Isoelectric Point: 7.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003226 | Metal-dependent protein hydrolase |
| PFam | PF03690 | Metal-dependent protein hydrolase |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 29079720 | A Global Survey of ATPase Activity in Plasmodium falciparum Asexual Blood Stagesand Gametocytes. | Ortega C, Frando A, ..., Grundner C | 10.1074/mcp.RA117.000088 |