Product Description: ribosomal protein L46, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.07 | 0.96 |
| Trophozoite | no data | 0.34 | 0.79 |
| Schizont | no data | 0.08 | 0.94 |
| Gametocyte | no data | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0626900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.011 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTA5
"Best" AlphaFill ligand hit: ETM (2-(trimethylammonium)ethyl thiol, Local RMSD=0.54) with 1QXA (Global RMSD=25.33)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103062
Most Similar Human Ortholog: Q9H2W6
TM-align score: 0.70 | RMSD: 3.83
Seq Identity: 0.18 | Length: 237 / 372
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000259494 | mitochondrial ribosomal protein L46 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 12 | 8 | 10 |
| disruptive | 10 | 38 | 27 | 56 |
| missense | 3 | 32 | 27 | 48 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 25 | 11 | 25 |
| disruptive | 24 | 97 | 45 | 115 |
| missense | 10 | 76 | 37 | 73 |
PlasmoDB Total SNPs: 116
Non-coding: 58 | Synonymous: 39 | Nonsynonymous: 19 | Stop Codon: 0
Protein Length: 372 | Molecular Weight (kDa): 45.099
UniProt ID(s): C6KTA5
PDB ID(s): None
Isoelectric Point: 7.19
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR040008 | 39S ribosomal protein L46, mitochondrial |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |