PF3D7_0627000

Genome location: Pf3D7_06_v3:1,084,110..1,087,609(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.07	0.96
Trophozoite	no data	0.04	0.98
Schizont	no data	0.02	0.99
Gametocyte	no data	0.43	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0627000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.991 | MFS: -2.321 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTA6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105653

Most Similar Human Ortholog: Q96C74

TM-align score: 0.34 | RMSD: 3.17

Seq Identity: 0.19 | Length: 53 / 110

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000145491	rhophilin associated tail protein 1 like

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	2
missense	0	0	0	0

PlasmoDB Total SNPs: 162

Non-coding: 155 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 110 | Molecular Weight (kDa): 13.193

UniProt ID(s): C6KTA6

PDB ID(s): None

Isoelectric Point: 5.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A