PF3D7_0627100

Genome location: Pf3D7_06_v3:1,087,078..1,094,389(+)

Genome classification: Core

Function and Localization

Product Description: ankyrin-repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0627100

Resistome Missense Mutations: Q283K, T600S, F1409L, W1458C

Resistome Compounds with Missense Mutations: MMV024101, MMV407834, MMV665928, MMV982556

Resistome # Samples with Disruptive Mutations: 7 (6 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -3.205 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTA7

"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=0.01) with 3Q9N (Global RMSD=1.97)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 235

Non-coding: 133 | Synonymous: 69 | Nonsynonymous: 33 | Stop Codon: 0

Protein Information

Protein Length: 1712 | Molecular Weight (kDa): 198.278

UniProt ID(s): C6KTA7

PDB ID(s): None

Isoelectric Point: 6.74

Protein Domain Annotations: