PF3D7_0627200 (PLC5)

Genome location: Pf3D7_06_v3:1,094,737..1,096,373(-)

Genome classification: Core

Function and Localization

Product Description: myosin light chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.04	0.97
Schizont	no data	0.02	0.98
Gametocyte	no data	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0627200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.189 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTA8

"Best" AlphaFill ligand hit: MPO (3[n-morpholino]propane sulfonic acid, Local RMSD=0.08) with 5I0I (Global RMSD=9.26)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130905

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	8	2	9
disruptive	4	16	13	17
missense	4	16	13	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	12	7	9
disruptive	4	35	12	32
missense	4	33	11	22

PlasmoDB Total SNPs: 79

Non-coding: 74 | Synonymous: 2 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 139 | Molecular Weight (kDa): 16.143

UniProt ID(s): C6KTA8

PDB ID(s): None

Isoelectric Point: 4.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand domain pair
PFam	PF13499	EF-hand domain
Superfamily	SSF47473	EF-hand domain pair