Genome location: Pf3D7_06_v3:1,096,654..1,098,696(-)
Genome classification: Core
Product Description: E3 ubiquitin-protein ligase RNF5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 6.3.2.19 (Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0061630 | ubiquitin protein ligase activity |
| Function | GO:0044390 | ubiquitin-like protein conjugating enzyme binding |
| Function | GO:0008270 | zinc ion binding |
| Process | GO:0071712 | ER-associated misfolded protein catabolic process |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 1.36 | 0.41 |
| Trophozoite | no data | 1.58 | 0.29 |
| Schizont | no data | 1.38 | 0.37 |
| Gametocyte | no data | 1.88 | 0.19 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0627300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.965 | MFS: -2.698 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTA9
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 6.3.2.19 | ubiquitin-protein ligase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102074
Most Similar Human Ortholog: A0A140TA09
TM-align score: 0.64 | RMSD: 1.89
Seq Identity: 0.49 | Length: 67 / 449
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000138942 | ring finger protein 185 |
| ENSG00000183574 | ring finger protein 5 |
| ENSG00000204308 | ring finger protein 5 |
| ENSG00000223767 | ring finger protein 5 |
| ENSG00000225452 | ring finger protein 5 |
| ENSG00000227277 | ring finger protein 5 |
| ENSG00000228405 | ring finger protein 5 |
| ENSG00000228907 | ring finger protein 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 16 | 16 | 24 |
| disruptive | 14 | 44 | 31 | 62 |
| missense | 9 | 41 | 31 | 51 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 41 | 21 | 31 |
| disruptive | 20 | 102 | 46 | 123 |
| missense | 13 | 89 | 39 | 87 |
PlasmoDB Total SNPs: 90
Non-coding: 58 | Synonymous: 14 | Nonsynonymous: 18 | Stop Codon: 0
Protein Length: 449 | Molecular Weight (kDa): 52.812
UniProt ID(s): C6KTA9
PDB ID(s): None
Isoelectric Point: 4.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001841 | Zinc finger, RING-type |
| InterPro | IPR017907 | Zinc finger, RING-type, conserved site |
| PFam | PF13920 | N/A |
| Superfamily | SSF57850 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |