PF3D7_0627600

Genome location: Pf3D7_06_v3:1,103,388..1,105,825(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.03	0.98
Schizont	no data	0.01	1.00
Gametocyte	no data	0.31	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0627600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -2.887 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTB2

"Best" AlphaFill ligand hit: AN2 (amp phosphoramidate, Local RMSD=3.84) with 3IED (Global RMSD=19.88)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533763

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	10	7	7
disruptive	11	51	32	68
missense	7	45	27	55

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	22	9	25
disruptive	26	133	51	110
missense	14	104	40	78

PlasmoDB Total SNPs: 111

Non-coding: 80 | Synonymous: 25 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 394 | Molecular Weight (kDa): 46.547

UniProt ID(s): C6KTB2

PDB ID(s): None

Isoelectric Point: 6.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A