Product Description: transportin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005643 | nuclear pore |
| Component | GO:0005634 | nucleus |
| Function | GO:0061608 | nuclear import signal receptor activity |
| Function | GO:0008139 | nuclear localization sequence binding |
| Function | GO:0008320 | protein transmembrane transporter activity |
| Process | GO:0006606 | protein import into nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.14 | 0.50 |
| Trophozoite | expressed | 1.05 | 0.46 |
| Schizont | expressed | 0.71 | 0.60 |
| Gametocyte | expressed | 0.94 | 0.52 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0627700
Resistome Missense Mutations: A964D
Resistome Compounds with Missense Mutations: SJ733
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.073 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1126400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTB3
"Best" AlphaFill ligand hit: PEU (2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-heptacosaoxadooctacontan-82-ol, Local RMSD=0.17) with 4OKH (Global RMSD=13.53)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101362
Most Similar Human Ortholog: S4R398
TM-align score: 0.88 | RMSD: 1.99
Seq Identity: 0.24 | Length: 192 / 1147
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000083312 | transportin 1 |
| ENSG00000105576 | transportin 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 26 | 25 | 44 |
| disruptive | 13 | 45 | 27 | 113 |
| missense | 8 | 37 | 25 | 86 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 73 | 42 | 57 |
| disruptive | 34 | 140 | 72 | 262 |
| missense | 19 | 108 | 53 | 141 |
PlasmoDB Total SNPs: 301
Non-coding: 253 | Synonymous: 36 | Nonsynonymous: 11 | Stop Codon: 1
Protein Length: 1147 | Molecular Weight (kDa): 132.838
PDB ID(s): None
Isoelectric Point: 4.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001494 | Importin-beta, N-terminal domain |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR040122 | Importin beta family |
| PFam | PF03810 | Importin-beta, N-terminal domain |
| PFam | PF13513 | |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |