PF3D7_0628400

Genome location: Pf3D7_06_v3:1,175,869..1,178,588(+)

Genome classification: Core

Function and Localization

Product Description: protease, putative

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.14	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0628400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.814 | MFS: -2.317 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1127100)

Relative Growth Rate: 1.03 ± 0.05
Confidence: 7.42

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1128600)

Modification: Disrupted | RMgm-4762

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4H7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_168022

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	12	8	25
disruptive	2	24	12	44
missense	2	23	9	32

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	31	13	28
disruptive	11	70	38	89
missense	8	45	30	70

PlasmoDB Total SNPs: 132

Non-coding: 115 | Synonymous: 16 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 339 | Molecular Weight (kDa): 40.641

UniProt ID(s): C0H4H7

PDB ID(s): None

Isoelectric Point: 6.8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026898	Intramembrane metalloprotease PrsW
PFam	PF13367	Intramembrane metalloprotease PrsW
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095