PF3D7_0628500

Genome location: Pf3D7_06_v3:1,178,630..1,180,100(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.14	0.91
Schizont	not expressed	0.02	0.98
Gametocyte	not expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0628500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.327 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTC0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532959

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	3	8	16
disruptive	1	6	2	22
missense	1	6	2	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	18	11	20
disruptive	3	27	23	71
missense	1	16	18	44

PlasmoDB Total SNPs: 65

Non-coding: 50 | Synonymous: 12 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 316 | Molecular Weight (kDa): 37.467

UniProt ID(s): C6KTC0

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A