PF3D7_0628600

Genome location: Pf3D7_06_v3:1,180,102..1,182,381(-)

Genome classification: Core

Function and Localization

Product Description: DNA methyltransferase 1-associated protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0035267	NuA4 histone acetyltransferase complex
Component	GO:0000812	Swr1 complex
Function	GO:0003714	transcription corepressor activity
Process	GO:0043968	histone H2A acetylation
Process	GO:0043967	histone H4 acetylation
Process	GO:0043486	histone exchange
Process	GO:0000122	negative regulation of transcription by RNA polymerase II

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.42	0.80
Trophozoite	not expressed	0.61	0.65
Schizont	not expressed	0.18	0.88
Gametocyte	not expressed	0.60	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0628600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -1.057 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1127300)

Relative Growth Rate: 0.34 ± 0.11
Confidence: 5.77

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1127300)

Modification: Disrupted | RMgm-3079

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTC1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102680

Most Similar Human Ortholog: Q5TG38

TM-align score: 0.52 | RMSD: 3.72

Seq Identity: 0.25 | Length: 156 / 385

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000178028	DNA methyltransferase 1 associated protein 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	5	23
disruptive	2	10	10	33
missense	2	10	10	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	30	11	23
disruptive	4	42	32	60
missense	2	30	26	44

PlasmoDB Total SNPs: 92

Non-coding: 84 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 385 | Molecular Weight (kDa): 46.557

UniProt ID(s): C6KTC1

PDB ID(s): None

Isoelectric Point: 9.8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009057	Homeobox-like domain superfamily
InterPro	IPR027109	SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1
InterPro	IPR032563	DAMP1, SANT/Myb-like domain
PFam	PF16282	DAMP1, SANT/Myb-like domain
Superfamily	SSF46689	Homeobox-like domain superfamily