PF3D7_0628700

Genome location: Pf3D7_06_v3:1,183,134..1,185,887(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.20	0.90
Trophozoite	no data	0.51	0.70
Schizont	no data	0.17	0.89
Gametocyte	no data	0.45	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0628700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -3.206 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTC2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533482

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	12	5	18
disruptive	3	40	31	103
missense	3	37	29	94

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	26	19	35
disruptive	16	144	69	110
missense	7	118	56	83

PlasmoDB Total SNPs: 36

Non-coding: 15 | Synonymous: 17 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 573 | Molecular Weight (kDa): 69.981

UniProt ID(s): C6KTC2

PDB ID(s): None

Isoelectric Point: 10.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104