PF3D7_0628900

Genome location: Pf3D7_06_v3:1,189,472..1,193,978(+)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	possibly expressed	0.27	0.84
Schizont	possibly expressed	0.03	0.98
Gametocyte	expressed	0.52	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0628900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.163 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTC4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532904

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	32	28	63
disruptive	26	101	98	250
missense	9	79	90	228

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	84	51	102
disruptive	55	306	188	374
missense	16	245	155	282

PlasmoDB Total SNPs: 100

Non-coding: 13 | Synonymous: 68 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 1442 | Molecular Weight (kDa): 174.751

UniProt ID(s): C6KTC4

PDB ID(s): None

Isoelectric Point: 8.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	N/A	N/A
Superfamily	N/A	N/A