Genome location: Pf3D7_06_v3:1,194,304..1,195,217(-)
Genome classification: Core
Product Description: glucosamine 6-phosphate N-acetyltransferase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.1.1 (Amino-acid N-acetyltransferase);2.3.1.4 (Glucosamine-phosphate N-acetyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0004343 | glucosamine 6-phosphate N-acetyltransferase activity |
| Process | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | not expressed | 0.19 | 0.88 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | not expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0629000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.229 | MFS: -3.365 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTC5
"Best" AlphaFill ligand hit: ACO (acetyl coenzyme *a, Local RMSD=9.36) with 4LX9 (Global RMSD=11.87)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 6 | 6 | 13 |
| disruptive | 1 | 13 | 7 | 32 |
| missense | 1 | 13 | 7 | 27 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 15 | 4 | 14 |
| disruptive | 4 | 33 | 20 | 40 |
| missense | 2 | 24 | 16 | 31 |
PlasmoDB Total SNPs: 14
Non-coding: 3 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 291 | Molecular Weight (kDa): 35.411
UniProt ID(s): C6KTC5
PDB ID(s): None
Isoelectric Point: 9.66
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000182 | GNAT domain |
| InterPro | IPR016181 | Acyl-CoA N-acyltransferase |
| PFam | PF00583 | GNAT domain |
| Superfamily | SSF55729 | Acyl-CoA N-acyltransferase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 29507322 | The Apicomplexa-specific glucosamine-6-phosphate N-acetyltransferase gene familyencodes a key enzyme for glycoconjugate synthesis with potential as therapeutictarget. | Cova M, Lopez-Gutierrez B, ..., Izquierdo L | 10.1038/s41598-018-22441-3 |
| 33082260 | Plasmodium falciparum Apicomplexan-Specific Glucosamine-6-Phosphate N-Acetyltransferase Is Key for Amino Sugar Metabolism and Asexual Blood Stage Development | Chi J, Cova M, ..., Izquierdo L | 10.1128/mBio.02045-20 |