Genome location: Pf3D7_06_v3:1,195,429..1,198,332(-)
Genome classification: Core
Product Description: nicotinate phosphoribosyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 6.3.4.21 (Nicotinate phosphoribosyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Function | GO:0004516 | nicotinate phosphoribosyltransferase activity |
| Process | GO:0009435 | NAD biosynthetic process |
| Process | GO:0034355 | NAD salvage |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.18 | 0.91 |
| Trophozoite | expressed | 0.36 | 0.78 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.21 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0629100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.829 | MFS: -3.036 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTC6
"Best" AlphaFill ligand hit: PCP (cprpp, Local RMSD=0.40) with 2I14 (Global RMSD=6.79)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 6.3.4.21 | nicotinate phosphoribosyltransferase | ATPCoAGDPUTPKCNGMPITPIMPIDPNAD+NADHPCMB... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102036
Most Similar Human Ortholog: Q6XQN6
TM-align score: 0.93 | RMSD: 2.01
Seq Identity: 0.31 | Length: 525 / 665
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000147813 | nicotinate phosphoribosyltransferase |
| ENSG00000278488 | nicotinate phosphoribosyltransferase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 15 | 13 | 31 |
| disruptive | 6 | 23 | 12 | 74 |
| missense | 6 | 23 | 12 | 67 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 41 | 21 | 33 |
| disruptive | 15 | 62 | 46 | 109 |
| missense | 12 | 55 | 42 | 81 |
PlasmoDB Total SNPs: 109
Non-coding: 79 | Synonymous: 25 | Nonsynonymous: 4 | Stop Codon: 1
Protein Length: 665 | Molecular Weight (kDa): 77.126
UniProt ID(s): C6KTC6
PDB ID(s): None
Isoelectric Point: 7.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006405 | Nicotinate phosphoribosyltransferase pncB-type |
| InterPro | IPR007229 | Nicotinate phosphoribosyltransferase family |
| InterPro | IPR036068 | Nicotinate phosphoribosyltransferase-like, C-terminal |
| InterPro | IPR040727 | Nicotinate phosphoribosyltransferase, N-terminal domain |
| InterPro | IPR041619 | Nicotinate phosphoribosyltransferase C-terminal domain |
| PFam | PF17767 | Nicotinate phosphoribosyltransferase, N-terminal domain |
| PFam | PF17956 | Nicotinate phosphoribosyltransferase C-terminal domain |
| Superfamily | SSF51690 | Nicotinate phosphoribosyltransferase-like, C-terminal |
| Superfamily | SSF54675 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 24747974 | Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum. | O'Hara JK, Kerwin LJ, ..., Llinas M | 10.1371/journal.pone.0094061 |