Genome location: Pf3D7_06_v3:1,209,083..1,213,867(+)
Genome classification: Core
Product Description: polyadenylate-binding protein 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.48 | 0.72 |
| Schizont | expressed | 0.10 | 0.93 |
| Gametocyte | expressed | 0.39 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0629400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.676 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTC9
"Best" AlphaFill ligand hit: M2M (1-methoxy-2-(2-methoxyethoxy)ethane, Local RMSD=2.32) with 4ED5 (Global RMSD=18.37)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102296
Most Similar Human Ortholog: Q9NX07
TM-align score: 0.29 | RMSD: 3.77
Seq Identity: 0.24 | Length: 99 / 780
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000180098 | tRNA selenocysteine 1 associated protein 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 19 | 9 | 37 |
| disruptive | 10 | 33 | 34 | 98 |
| missense | 3 | 20 | 26 | 73 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 50 | 24 | 53 |
| disruptive | 24 | 136 | 101 | 258 |
| missense | 6 | 97 | 75 | 139 |
PlasmoDB Total SNPs: 172
Non-coding: 112 | Synonymous: 49 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 780 | Molecular Weight (kDa): 90.783
UniProt ID(s): C6KTC9
PDB ID(s): None
Isoelectric Point: 4.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |