Genome location: Pf3D7_06_v3:1,213,102..1,217,313(-)
Genome classification: Core
Product Description: amino acid transporter AAT1
SignalP Peptide: N/A
# Transmembrane Domains: 9
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0020020 | food vacuole |
Component | GO:0005886 | plasma membrane |
Function | GO:0015171 | amino acid transmembrane transporter activity |
Function | GO:0042910 | xenobiotic transmembrane transporter activity |
Process | GO:0003333 | amino acid transmembrane transport |
Process | GO:0006865 | amino acid transport |
Process | GO:1902349 | response to chloroquine |
Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.77 | 0.64 |
Trophozoite | expressed | 0.70 | 0.62 |
Schizont | expressed | 0.17 | 0.90 |
Gametocyte | expressed | 0.27 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0629500
Resistome Missense Mutations: V185L, F230L, K238N, F377L, P380S
Resistome Compounds with Missense Mutations: MMV006901, MMV011895, MMV668399
Resistome # Samples with Disruptive Mutations: 9 (8 missense, 8 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.143 | MFS: -2.882 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1128300)
Modification: Disrupted | RMgm-5357
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTD0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 2 | 15 | 8 | 28 |
disruptive | 8 | 24 | 11 | 54 |
missense | 8 | 23 | 11 | 43 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 4 | 38 | 29 | 37 |
disruptive | 21 | 69 | 54 | 142 |
missense | 13 | 56 | 50 | 82 |
PlasmoDB Total SNPs: 162
Non-coding: 141 | Synonymous: 14 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 606 | Molecular Weight (kDa): 68.858
UniProt ID(s): C6KTD0
PDB ID(s): None
Isoelectric Point: 10.15
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR013057 | Amino acid transporter, transmembrane domain |
PFam | PF01490 | Amino acid transporter, transmembrane domain |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
29326268 | Mapping the malaria parasite druggable genome by using in vitro evolution andchemogenomics. | Cowell AN, Istvan ES, ..., Winzeler EA | 10.1126/science.aan4472 |
29410428 | Heterologous Expression of a Novel Drug Transporter from the Malaria ParasiteAlters Resistance to Quinoline Antimalarials. | Tindall SM, Vallieres C, ..., Avery SV | 10.1038/s41598-018-20816-0 |
35121625 | Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomycespombe is regulated by TORC2 and Gsk3 | Wang T, Woodman P, Humphrey SJ, Petersen J | 10.26508/lsa.202101082 |
37169919 | Chloroquine resistance evolution in Plasmodium falciparum is mediated by theputative amino acid transporter AAT1 | Amambua-Ngwa A, Button-Simons KA, ..., Anderson TJC | 10.1038/s41564-023-01377-z |
35368081 | In silico target-based strain engineering of Saccharomyces cerevisiae for terpeneprecursor improvement | Paramasivan K, Abdulla A, Gupta N, Mutturi S | 10.1093/intbio/zyac003 |
36542676 | Resolving drug selection and migration in an inbred South American Plasmodiumfalciparum population with identity-by-descent analysis | Carrasquilla M, Early AM, ..., Corredor V | 10.1371/journal.ppat.1010993 |