PF3D7_0629600

Genome location: Pf3D7_06_v3:1,217,321..1,219,766(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal RNA-processing protein 7, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0032545	CURI complex
Component	GO:0034456	UTP-C complex
Process	GO:0006364	rRNA processing
Process	GO:0000028	ribosomal small subunit assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.68	0.67
Trophozoite	no data	0.45	0.75
Schizont	no data	0.08	0.95
Gametocyte	no data	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0629600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.185 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTD1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533114

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	4	5	13
disruptive	1	14	11	41
missense	1	14	9	38

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	15	13	24
disruptive	5	58	37	97
missense	2	39	27	66

PlasmoDB Total SNPs: 102

Non-coding: 91 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 259 | Molecular Weight (kDa): 30.887

UniProt ID(s): C6KTD1

PDB ID(s): None

Isoelectric Point: 10.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024326	Ribosomal RNA-processing protein 7, C-terminal domain
InterPro	IPR035979	RNA-binding domain superfamily
InterPro	IPR040446	Ribosomal RNA-processing protein 7
PFam	PF12923	Ribosomal RNA-processing protein 7, C-terminal domain
Superfamily	SSF54928	RNA-binding domain superfamily