Genome location: Pf3D7_06_v3:1,221,309..1,243,267(+)
Genome classification: Core
Product Description: SET domain protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.1.43 (Transferred entry: 2.1.1.354)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0035097 | histone methyltransferase complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0042800 | histone methyltransferase activity (H3-K4 specific) |
| Function | GO:0005515 | protein binding |
| Function | GO:0019904 | protein domain specific binding |
| Process | GO:0051568 | histone H3-K4 methylation |
| Process | GO:0045893 | positive regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.94 | 0.29 |
| Trophozoite | expressed | 2.69 | 0.12 |
| Schizont | expressed | 1.75 | 0.36 |
| Gametocyte | expressed | 1.85 | 0.24 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0629700
Resistome Missense Mutations: Q4236L, N4315K
Resistome Compounds with Missense Mutations: AN13762, Lopinavir
Resistome # Samples with Disruptive Mutations: 5 (5 missense, 4 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.983 | MFS: -2.801 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.1.1.43 | histone-lysine N-methyltransferase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101262
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 6753
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000099381 | SET domain containing 1A, histone lysine methyltransferase |
| ENSG00000139718 | SET domain containing 1B, histone lysine methyltransferase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 228 | 113 | 289 |
| disruptive | 191 | 760 | 433 | 1003 |
| missense | 101 | 600 | 368 | 848 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 82 | 437 | 226 | 382 |
| disruptive | 425 | 1698 | 776 | 1716 |
| missense | 225 | 1282 | 621 | 1114 |
PlasmoDB Total SNPs: 774
Non-coding: 157 | Synonymous: 388 | Nonsynonymous: 229 | Stop Codon: 0
Protein Length: 6753 | Molecular Weight (kDa): 796.045
UniProt ID(s): C6KTD2
PDB ID(s): None
Isoelectric Point: 8.77
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001214 | SET domain |
| InterPro | IPR001487 | Bromodomain |
| InterPro | IPR001965 | Zinc finger, PHD-type |
| InterPro | IPR011011 | Zinc finger, FYVE/PHD-type |
| InterPro | IPR036427 | Bromodomain-like superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF47370 | Bromodomain-like superfamily |
| Superfamily | SSF57903 | Zinc finger, FYVE/PHD-type |
| Superfamily | SSF82199 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34268135 | The Transcription Factor PfAP2-O Influences Virulence Gene Transcription andSexual Development in Plasmodium falciparum. | Cubillos EFG, Prata IO, ..., Wunderlich G | https://pubmed.ncbi.nlm.nih.gov/34268135/ |
| 38181050 | The Cross-Regulation Between Set1, Clr4, and Lsd1/2 in Schizosaccharomyces pombe | Liu H, Marayati BF, ..., Reid KZ | 10.1371/journal.pgen.1011107 |