Product Description: cullin-2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031461 | cullin-RING ubiquitin ligase complex |
| Component | GO:0044310 | osmiophilic body |
| Function | GO:0005515 | protein binding |
| Function | GO:0031625 | ubiquitin protein ligase binding |
| Function | GO:0004842 | ubiquitin-protein transferase activity |
| Process | GO:0000082 | G1/S transition of mitotic cell cycle |
| Process | GO:0016567 | protein ubiquitination |
| Process | GO:0051726 | regulation of cell cycle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.46 | 0.78 |
| Trophozoite | not expressed | 0.66 | 0.63 |
| Schizont | not expressed | 0.25 | 0.83 |
| Gametocyte | not expressed | 0.63 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0629800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.124 | MFS: -3.086 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTD3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 36 | 19 | 68 |
| disruptive | 29 | 72 | 53 | 129 |
| missense | 20 | 58 | 46 | 103 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 90 | 41 | 76 |
| disruptive | 44 | 187 | 96 | 260 |
| missense | 26 | 127 | 79 | 184 |
PlasmoDB Total SNPs: 131
Non-coding: 33 | Synonymous: 70 | Nonsynonymous: 28 | Stop Codon: 0
Protein Length: 1129 | Molecular Weight (kDa): 136.343
UniProt ID(s): C6KTD3
PDB ID(s): None
Isoelectric Point: 8.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001373 | Cullin, N-terminal |
| InterPro | IPR016158 | Cullin homology domain |
| InterPro | IPR016159 | Cullin repeat-like-containing domain superfamily |
| InterPro | IPR019559 | Cullin protein, neddylation domain |
| InterPro | IPR036317 | Cullin homology domain superfamily |
| InterPro | IPR036390 | Winged helix DNA-binding domain superfamily |
| PFam | PF00888 | Cullin, N-terminal |
| Superfamily | SSF46785 | Winged helix DNA-binding domain superfamily |
| Superfamily | SSF74788 | Cullin repeat-like-containing domain superfamily |
| Superfamily | SSF75632 | Cullin homology domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 27432909 | Comparative Proteomics and Functional Analysis Reveal a Role of Plasmodiumfalciparum Osmiophilic Bodies in Malaria Parasite Transmission. | Suarez-Cortes P, Sharma V, ..., Alano P | 10.1074/mcp.M116.060681 |
| 33214620 | Characterization of Plasmodium falciparum NEDD8 and identification of cullins asits substrates. | Bhattacharjee M, Adhikari N, ..., Sijwali PS | 10.1038/s41598-020-77001-5 |