Product Description: CRAL/TRIO domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.09 | 0.95 |
| Trophozoite | no data | 0.07 | 0.95 |
| Schizont | no data | 0.04 | 0.97 |
| Gametocyte | no data | 0.10 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0629900
Resistome Missense Mutations: V126L, E156V
Resistome Compounds with Missense Mutations: Lopinavir, MMV024101
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.645 | MFS: -2.867 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTD4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100867
Most Similar Human Ortholog: O43304
TM-align score: 0.68 | RMSD: 3.18
Seq Identity: 0.20 | Length: 264 / 328
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000103184 | SEC14 like lipid binding 5 |
| ENSG00000129657 | SEC14 like lipid binding 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 17 | 6 | 27 |
| disruptive | 4 | 10 | 12 | 26 |
| missense | 2 | 10 | 10 | 23 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 36 | 17 | 14 |
| disruptive | 7 | 36 | 27 | 99 |
| missense | 3 | 26 | 21 | 66 |
PlasmoDB Total SNPs: 146
Non-coding: 130 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 2
Protein Length: 328 | Molecular Weight (kDa): 38.073
UniProt ID(s): C6KTD4
PDB ID(s): None
Isoelectric Point: 8.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001251 | CRAL-TRIO lipid binding domain |
| InterPro | IPR036273 | CRAL/TRIO, N-terminal domain superfamily |
| InterPro | IPR036865 | CRAL-TRIO lipid binding domain superfamily |
| PFam | PF00650 | CRAL-TRIO lipid binding domain |
| Superfamily | SSF46938 | CRAL/TRIO, N-terminal domain superfamily |
| Superfamily | SSF52087 | CRAL-TRIO lipid binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |