PF3D7_0630000

Genome location: Pf3D7_06_v3:1,252,052..1,253,985(-)

Genome classification: Core

Function and Localization

Product Description: CPW-WPC family protein

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.44	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0630000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -1.785 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTD5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139424

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	13	7	9
disruptive	3	21	13	28
missense	3	20	13	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	17	13	16
disruptive	5	39	25	68
missense	5	35	24	54

PlasmoDB Total SNPs: 129

Non-coding: 116 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 280 | Molecular Weight (kDa): 33.083

UniProt ID(s): C6KTD5

PDB ID(s): None

Isoelectric Point: 4.27

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006387	CPW-WPC domain
PFam	PF09717	CPW-WPC domain
Superfamily	N/A	N/A