PF3D7_0630100

Genome location: Pf3D7_06_v3:1,254,330..1,256,987(-)

Genome classification: Core

Function and Localization

Product Description: alpha/beta hydrolase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.21	0.90
Trophozoite	no data	0.12	0.93
Schizont	no data	0.09	0.95
Gametocyte	no data	0.12	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0630100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.997 | MFS: -2.017 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1128900)

Modification: Disrupted | RMgm-3084

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTD6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532814

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	34	15	39
disruptive	32	108	57	121
missense	19	88	44	104

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	71	25	32
disruptive	60	218	91	181
missense	37	169	71	118

PlasmoDB Total SNPs: 135

Non-coding: 35 | Synonymous: 53 | Nonsynonymous: 47 | Stop Codon: 0

Protein Information

Protein Length: 677 | Molecular Weight (kDa): 79.364

UniProt ID(s): C6KTD6

PDB ID(s): None

Isoelectric Point: 8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	N/A	N/A
Superfamily	SSF53474	Alpha/Beta hydrolase fold