PF3D7_0630200 (PSOP6)

Genome location: Pf3D7_06_v3:1,258,880..1,259,939(+)

Genome classification: Core

Function and Localization

Product Description: secreted ookinete protein, putative

SignalP Peptide: MNYSMFCICLFIWCLVEN

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	0.99
Trophozoite	no data	0.00	1.00
Schizont	no data	0.01	1.00
Gametocyte	no data	0.60	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0630200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.126 | MFS: -3.114 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1129000)

Relative Growth Rate: 1.05 ± 0.13
Confidence: 5.46

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1129000)

Modification: Disrupted | RMgm-3085

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTD7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130603

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	5	1	6
disruptive	1	11	2	9
missense	1	10	1	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	6	3	6
disruptive	2	24	4	23
missense	1	21	4	17

PlasmoDB Total SNPs: 47

Non-coding: 36 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 135 | Molecular Weight (kDa): 15.874

UniProt ID(s): C6KTD7

PDB ID(s): None

Isoelectric Point: 4.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A