About Gene List

PF3D7_0630400

Genome location: Pf3D7_06_v3:1,271,808..1,274,009(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.09 0.94
Schizont expressed 0.58 0.67
Gametocyte expressed 0.51 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0630400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.562 | MFS: -1.286 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1129200)

  • Relative Growth Rate: 1.02 ± 0.16
  • Confidence: 5.11

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1129200)

Modification: Disrupted | RMgm-3087

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTD9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533286

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 16 1 14
disruptive 12 28 11 58
missense 9 21 7 38

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 28 5 26
disruptive 19 64 53 91
missense 12 41 37 55

PlasmoDB Total SNPs: 109

Non-coding: 76 | Synonymous: 22 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 389 | Molecular Weight (kDa): 45.8

UniProt ID(s): C6KTD9

PDB ID(s): None

Isoelectric Point: 9.1

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001893 Cysteine-rich Golgi apparatus protein 1 repeat
PFam PF00839 Cysteine-rich Golgi apparatus protein 1 repeat
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095