Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | not expressed | 0.02 | 0.99 |
Trophozoite | not expressed | 0.09 | 0.94 |
Schizont | expressed | 0.58 | 0.67 |
Gametocyte | expressed | 0.51 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0630400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.562 | MFS: -1.286 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1129200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1129200)
Modification: Disrupted | RMgm-3087
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTD9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 6 | 16 | 1 | 14 |
disruptive | 12 | 28 | 11 | 58 |
missense | 9 | 21 | 7 | 38 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 8 | 28 | 5 | 26 |
disruptive | 19 | 64 | 53 | 91 |
missense | 12 | 41 | 37 | 55 |
PlasmoDB Total SNPs: 109
Non-coding: 76 | Synonymous: 22 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 389 | Molecular Weight (kDa): 45.8
UniProt ID(s): C6KTD9
PDB ID(s): None
Isoelectric Point: 9.1
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR001893 | Cysteine-rich Golgi apparatus protein 1 repeat |
PFam | PF00839 | Cysteine-rich Golgi apparatus protein 1 repeat |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |