Product Description: deubiquitinating enzyme MINDY, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.19.12 (Ubiquitinyl hydrolase 1)
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.22 | 0.89 |
| Trophozoite | not expressed | 0.68 | 0.62 |
| Schizont | not expressed | 0.58 | 0.64 |
| Gametocyte | not expressed | 0.69 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0630600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.136 | MFS: -2.854 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTE1
"Best" AlphaFill ligand hit: NCA (nicotinamide, Local RMSD=11.84) with 7WR3 (Global RMSD=20.36)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.19.12 | ubiquitinyl hydrolase 1 | KClNEMDTTEDTAEGTARNAisiRNApeptidesAntibodyubiquitinLDN-574442-propenal... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104448
Most Similar Human Ortholog: X6RC97
TM-align score: 0.88 | RMSD: 2.04
Seq Identity: 0.37 | Length: 161 / 935
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000148481 | MINDY lysine 48 deubiquitinase 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 26 | 46 | 18 | 47 |
| disruptive | 30 | 82 | 38 | 108 |
| missense | 9 | 43 | 24 | 69 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 39 | 89 | 31 | 43 |
| disruptive | 58 | 170 | 76 | 242 |
| missense | 18 | 97 | 49 | 135 |
PlasmoDB Total SNPs: 142
Non-coding: 67 | Synonymous: 59 | Nonsynonymous: 16 | Stop Codon: 0
Protein Length: 935 | Molecular Weight (kDa): 110.121
UniProt ID(s): C6KTE1
PDB ID(s): None
Isoelectric Point: 5.66
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR025257 | Deubiquitinating enzyme MINDY-3/4, conserved domain |
| InterPro | IPR039785 | Deubiquitinating enzyme MINDY-3/4 |
| PFam | PF13898 | Deubiquitinating enzyme MINDY-3/4, conserved domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |