PF3D7_0630800

Genome location: Pf3D7_06_v3:1,288,066..1,290,942(+)

Genome classification: Core

Function and Localization

Product Description: TPH domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.02	0.99
Schizont	not expressed	0.07	0.96
Gametocyte	possibly expressed	0.70	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0630800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.147 | MFS: -3.085 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTE3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532898

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	15	9	15
disruptive	5	39	19	42
missense	4	36	15	38

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	23	12	18
disruptive	27	69	34	74
missense	13	59	28	55

PlasmoDB Total SNPs: 184

Non-coding: 160 | Synonymous: 15 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 391 | Molecular Weight (kDa): 48.318

UniProt ID(s): C6KTE3

PDB ID(s): None

Isoelectric Point: 9.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR043597	Trichohyalin-plectin-homology domain
PFam	PF13868	Trichohyalin-plectin-homology domain
Superfamily	N/A	N/A