PF3D7_0631000

Genome location: Pf3D7_06_v3:1,293,965..1,296,496(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005680	anaphase-promoting complex
Component	GO:0005737	cytoplasm
Process	GO:0031145	anaphase-promoting complex-dependent catabolic process
Process	GO:0051301	cell division
Process	GO:0007091	metaphase/anaphase transition of mitotic cell cycle
Process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition
Process	GO:0016567	protein ubiquitination

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.06	0.96
Schizont	no data	0.18	0.87
Gametocyte	no data	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0631000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -2.938 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1129800)

Relative Growth Rate: 1.07 ± 0.14
Confidence: 5.33

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1129800)

Modification: Disrupted | RMgm-3090

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KTE5

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=2.56) with 5LVV (Global RMSD=11.10)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_116571

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 163

Non-coding: 141 | Synonymous: 18 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 285 | Molecular Weight (kDa): 33.498

UniProt ID(s): C6KTE5

PDB ID(s): None

Isoelectric Point: 7.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR019734	Tetratricopeptide repeat
PFam	PF13181	Tetratricopeptide repeat
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily