Genome location: Pf3D7_06_v3:1,333,013..1,334,035(+)
Genome classification: SubtelomericHypervariable
Product Description: stevor
SignalP Peptide: MKMYYLKMLLFNFLINVLVLP
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0033644 | host cell membrane |
| Component | GO:0020008 | rhoptry |
| Process | GO:0044409 | entry into host |
| Process | GO:0020013 | modulation by symbiont of host erythrocyte aggregation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | nd | 1.00 |
| Trophozoite | expressed | 0.00 | 1.00 |
| Schizont | expressed | 0.00 | 1.00 |
| Gametocyte | possibly expressed | 0.00 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0631900
Resistome Missense Mutations: K2N, M3L, C180Y
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.254 | MFS: -2.854 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KTF1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 488
Non-coding: 35 | Synonymous: 114 | Nonsynonymous: 339 | Stop Codon: 0
Protein Length: 303 | Molecular Weight (kDa): 34.109
UniProt ID(s): C6KTF1, Q2XR10, Q2XR17, Q2XR18, Q2XR23, Q2XR24
PDB ID(s): None
Isoelectric Point: 9.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006374 | Variant surface antigen Stevor |
| PFam | PF17410 | Variant surface antigen Stevor |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16896206 | Programmed transcription of the var gene family, but not of stevor, in Plasmodiumfalciparum gametocytes. | Sharp S, Lavstsen T, ..., Sutherland CJ | 10.1128/EC.00029-06 |
| 25011110 | STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. | Niang M, Bei AK, ..., Preiser PR | 10.1016/j.chom.2014.06.004 |
| 26173856 | A comparative study of the localization and membrane topology of members of theRIFIN, STEVOR and PfMC-2TM protein families in Plasmodium falciparum-infectederythrocytes. | Bachmann A, Scholz JA, ..., Petter M | 10.1186/s12936-015-0784-2 |
| 27136945 | Plasmodium falciparum STEVOR phosphorylation regulates host erythrocytedeformability enabling malaria parasite transmission. | Naissant B, Dupuy F, ..., Lavazec C | 10.1182/blood-2016-01-690776 |
| 31363031 | Dissecting the Gene Expression, Localization, Membrane Topology, and Function ofthe Plasmodium falciparum S TEVOR Protein Family | Wichers JS, Scholz JAM, ..., Bachmann A | 10.1128/mBio.01500-19 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |