PF3D7_0700100 (VAR)

Genome location: Pf3D7_07_v3:20,307..28,083(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte membrane protein 1, PfEMP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0700100

Resistome Missense Mutations: N3K, R1504L, N1862D, I1994L, S2254N, K2262R

Resistome Compounds with Missense Mutations: AN13762, MMV407834

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.878 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZY53

"Best" AlphaFill ligand hit: 3PO (triphosphate, Local RMSD=1.99) with 5MZA (Global RMSD=5.40)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 2665

Non-coding: 403 | Synonymous: 735 | Nonsynonymous: 1509 | Stop Codon: 18

Protein Information

Protein Length: 2286 | Molecular Weight (kDa): 256.072

UniProt ID(s): A0A143ZY53, A0A5P1A2F1

PDB ID(s): None

Isoelectric Point: 4.97

Protein Domain Annotations: