About Gene List

PF3D7_0701900

Genome location: Pf3D7_07_v3:79,450..83,835(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0044538 host cell periphery
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.82 0.38
Trophozoite possibly expressed 0.29 0.85
Schizont expressed 0.32 0.82
Gametocyte not expressed 0.16 0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0701900

Resistome Missense Mutations: I259L, R344S

Resistome Compounds with Missense Mutations: AN13762, MMV084978

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.831 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC48

"Best" AlphaFill ligand hit: FUM (fumaric acid, Local RMSD=1.91) with 5HW2 (Global RMSD=18.31)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145788

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 35 31 19 28
disruptive 167 221 83 191
missense 126 160 55 129

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 38 61 28 35
disruptive 219 348 110 218
missense 160 234 75 135

PlasmoDB Total SNPs: 481

Non-coding: 120 | Synonymous: 89 | Nonsynonymous: 264 | Stop Codon: 8

Protein Information

Protein Length: 964 | Molecular Weight (kDa): 112.696

UniProt ID(s): D9HMQ2, D9HMR4, D9HMR5, D9HMS2, D9HMS4, D9HMT1, D9HMT4, D9HMT7, D9HMU0, D9HMU2, D9HMU4, D9HMU9, D9HMV0, D9HMV1, Q8IC48

PDB ID(s): None

Isoelectric Point: 8.62

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
27777305 Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte. Davies HM, Thalassinos K, Osborne AR 10.1074/jbc.M116.761213
29138437 Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the innermembrane complex and is required for Plasmodium parasite development. Saini E, Zeeshan M, ..., Tewari R 10.1038/s41598-017-15781-z
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g