About Gene List

PF3D7_0702300 (STARP)

Genome location: Pf3D7_07_v3:95,444..99,176(+)

Genome classification: Core

Function and Localization

Product Description: sporozoite threonine and asparagine-rich protein

SignalP Peptide: MIHIFYRTAIFTLSIWTTLLYS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.00 0.56
Trophozoite not expressed 0.13 0.93
Schizont not expressed 0.10 0.94
Gametocyte not expressed 0.06 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0702300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.119 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC44

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
P0C6X4 Replicase polyprotein 1ab OrthoMCL BLAST cmdc.202100576, 6bUS9975885, Compound 6US9975885, Compound 13US9975885, Compound 14...

Orthology Information

Ortholog Group (OrthoMCL): OG6_533078

No human ortholog(s)

Protein Information

Protein Length: 594 | Molecular Weight (kDa): 66.004

UniProt ID(s): B0Z860, B0Z8C8, B0Z8D0, B0Z8G0, B0Z8G8, B0Z8H0, B0Z8H9, B0Z8I0, B0Z8I2, Q26021, Q8IC44

PDB ID(s): None

Isoelectric Point: 4.91

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 13 8 20
disruptive 18 49 33 72
missense 13 43 29 53

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 25 12 26
disruptive 30 124 68 127
missense 22 102 52 81

PlasmoDB Total SNPs: 267

Non-coding: 142 | Synonymous: 72 | Nonsynonymous: 53 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI/Link
7935600 Cloning and characterization of a novel Plasmodium falciparum sporozoite surfaceantigen, STARP. Fidock DA, Bottius E, ..., et al. 10.1016/0166-6851(94)00012-3
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
29104210 A Large Size Chimeric Highly Immunogenic Peptide Presents Multistage PlasmodiumAntigens as a Vaccine Candidate System against Malaria Lozano JM, Varela Y, ..., Patarroyo ME 10.3390/molecules22111837
35715803 Cellular and antibody response in GMZ2-vaccinated Gabonese volunteers in acontrolled human malaria infection trial Nouatin O, Ibanez J, ..., Mordmuller B 10.1186/s12936-022-04169-8