Product Description: small exported membrane protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0020036 | Maurer's cleft |
Component | GO:1903561 | extracellular vesicle |
Component | GO:0030430 | host cell cytoplasm |
Component | GO:0033644 | host cell membrane |
Component | GO:0005634 | nucleus |
Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 1.08 | 0.56 |
Trophozoite | expressed | 0.95 | 0.54 |
Schizont | expressed | 0.22 | 0.87 |
Gametocyte | expressed | 0.26 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0702400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.346 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IC43
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 169
Non-coding: 165 | Synonymous: 0 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 123 | Molecular Weight (kDa): 14.195
UniProt ID(s): Q8IC43
PDB ID(s): None
Isoelectric Point: 10.01
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
23950716 | Identification of new PNEPs indicates a substantial non-PEXEL exportome andunderpins common features in Plasmodium falciparum protein export. | Heiber A, Kruse F, ..., Spielmann T | 10.1371/journal.ppat.1003546 |
25062022 | Characterization of the small exported Plasmodium falciparum membrane proteinSEMP1. | Dietz O, Rusch S, ..., Beck HP | 10.1371/journal.pone.0103272 |
28252383 | Plasmodium falciparum parasites deploy Rhop H2 into the host erythrocyte to obtainnutrients, grow and replicate | Counihan NA, Chisholm SA, ..., de Koning-Ward TF | 10.7554/eLife.23217 |
28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |