About Gene List

PF3D7_0702400 (SEMP1)

Genome location: Pf3D7_07_v3:100,338..103,399(+)

Genome classification: Core

Function and Localization

Product Description: small exported membrane protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:1903561 extracellular vesicle
Component GO:0030430 host cell cytoplasm
Component GO:0033644 host cell membrane
Component GO:0005634 nucleus
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.08 0.56
Trophozoite expressed 0.95 0.54
Schizont expressed 0.22 0.87
Gametocyte expressed 0.26 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0702400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -1.346 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC43

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533511

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 169

Non-coding: 165 | Synonymous: 0 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 123 | Molecular Weight (kDa): 14.195

UniProt ID(s): Q8IC43

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
23950716 Identification of new PNEPs indicates a substantial non-PEXEL exportome andunderpins common features in Plasmodium falciparum protein export. Heiber A, Kruse F, ..., Spielmann T 10.1371/journal.ppat.1003546
25062022 Characterization of the small exported Plasmodium falciparum membrane proteinSEMP1. Dietz O, Rusch S, ..., Beck HP 10.1371/journal.pone.0103272
28252383 Plasmodium falciparum parasites deploy Rhop H2 into the host erythrocyte to obtainnutrients, grow and replicate Counihan NA, Chisholm SA, ..., de Koning-Ward TF 10.7554/eLife.23217
28944300 Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. Abdi A, Yu L, ..., Rayner J 10.12688/wellcomeopenres.11910.2
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596