About Gene List

PF3D7_0702500

Genome location: Pf3D7_07_v3:104,012..106,731(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:1903561 extracellular vesicle
Component GO:0030430 host cell cytoplasm
Component GO:0070258 inner membrane pellicle complex
Component GO:0005634 nucleus
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.46 0.80
Trophozoite expressed 0.59 0.71
Schizont expressed 0.07 0.96
Gametocyte not expressed 0.08 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0702500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 2.017 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC42

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532357

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 6 5 16
disruptive 15 20 6 27
missense 13 17 6 26

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 20 18 21
disruptive 24 47 36 98
missense 19 39 36 71

PlasmoDB Total SNPs: 106

Non-coding: 96 | Synonymous: 1 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 253 | Molecular Weight (kDa): 27.673

UniProt ID(s): Q8IC42

PDB ID(s): None

Isoelectric Point: 8.76

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
23950716 Identification of new PNEPs indicates a substantial non-PEXEL exportome andunderpins common features in Plasmodium falciparum protein export. Heiber A, Kruse F, ..., Spielmann T 10.1371/journal.ppat.1003546
25062022 Characterization of the small exported Plasmodium falciparum membrane proteinSEMP1. Dietz O, Rusch S, ..., Beck HP 10.1371/journal.pone.0103272
28944300 Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. Abdi A, Yu L, ..., Rayner J 10.12688/wellcomeopenres.11910.2
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
33774908 Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. Jonsdottir TK, Counihan NA, ..., Gilson PR 10.1111/cmi.13332