PF3D7_0702600

Genome location: Pf3D7_07_v3:109,915..110,178(+)

Genome classification: Core

Function and Localization

Product Description: chitinase, fragment

SignalP Peptide: MKFYISLFLIIFSFLSGSLT

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.03	0.98
Trophozoite	possibly expressed	0.01	1.00
Schizont	possibly expressed	0.01	1.00
Gametocyte	possibly expressed	0.03	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0702600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: -2.679 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I6S7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533664

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	8	2	10
disruptive	1	10	6	24
missense	1	10	6	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	14	3	7
disruptive	2	27	11	30
missense	2	23	10	19

PlasmoDB Total SNPs: 7

Non-coding: 0 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 87 | Molecular Weight (kDa): 9.888

UniProt ID(s): Q8I6S7

PDB ID(s): None

Isoelectric Point: 9.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A