PF3D7_0702900

Genome location: Pf3D7_07_v3:112,576..114,405(-)

Genome classification: Core

Function and Localization

Product Description: centrin, putative

SignalP Peptide: MKLHVSLLYFFFLFLTFFNILKA

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0702900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.269 | MFS: -1.176 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0800600)

• Relative Growth Rate: 0.98 ± 0.13
• Confidence: 5.47

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PbANKA_0800600)

Modification: Disrupted | RMgm-4958

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4K1

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127054

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 137

Non-coding: 130 | Synonymous: 2 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 107 | Molecular Weight (kDa): 12.639

UniProt ID(s): C0H4K1

PDB ID(s): None

Isoelectric Point: 4.11

Protein Domain Annotations: