Product Description: cytosolic iron-sulfur assembly component 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0097361 | CIA complex |
| Process | GO:0016226 | iron-sulfur cluster assembly |
| Process | GO:0097428 | protein maturation by iron-sulfur cluster transfer |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.12 | 0.94 |
| Trophozoite | possibly expressed | 0.08 | 0.95 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | not expressed | 0.10 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0703100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -3.239 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IC39
"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=14.20) with 8DKT (Global RMSD=22.64)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102398
Most Similar Human Ortholog: J3KS95
TM-align score: 0.93 | RMSD: 1.44
Seq Identity: 0.51 | Length: 104 / 180
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000166595 | cytosolic iron-sulfur assembly component 2B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 10 | 5 | 21 |
| disruptive | 1 | 7 | 10 | 21 |
| missense | 1 | 7 | 9 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 16 | 17 | 16 |
| disruptive | 3 | 29 | 18 | 50 |
| missense | 2 | 24 | 15 | 26 |
PlasmoDB Total SNPs: 54
Non-coding: 44 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 180 | Molecular Weight (kDa): 21.268
UniProt ID(s): Q8IC39
PDB ID(s): None
Isoelectric Point: 4.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002744 | MIP18 family-like |
| InterPro | IPR034904 | Fe-S cluster assembly domain superfamily |
| InterPro | IPR039796 | MIP18 family |
| PFam | PF01883 | MIP18 family-like |
| Superfamily | SSF117916 | Fe-S cluster assembly domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 30346997 | Branched late-steps of the cytosolic iron-sulphur cluster assembly machinery ofTrypanosoma brucei | Tonini ML, Pena-Diaz P, ..., Lukes J | 10.1371/journal.ppat.1007326 |
| 25667230 | CIA2 deficiency results in impaired oxidative stress response and enhancedintracellular basal UPR activity in Saccharomyces cerevisiae | Zhao W, Zheng HZ, ..., Liu XG | 10.1093/femsle/fnv013 |