About Gene List

PF3D7_0703200

Genome location: Pf3D7_07_v3:122,013..127,441(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.28 0.87
Trophozoite expressed 1.13 0.45
Schizont expressed 0.89 0.56
Gametocyte expressed 0.73 0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0703200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.289 | MFS: -2.602 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC38

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_184637

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 86 38 73
disruptive 127 346 145 290
missense 74 271 112 224

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 33 141 57 75
disruptive 201 564 211 371
missense 121 426 159 234

PlasmoDB Total SNPs: 316

Non-coding: 87 | Synonymous: 103 | Nonsynonymous: 126 | Stop Codon: 0

Protein Information

Protein Length: 1540 | Molecular Weight (kDa): 182.542

UniProt ID(s): Q8IC38

PDB ID(s): None

Isoelectric Point: 6.33

Protein Domain Annotations:

Source Family ID Description
InterPro IPR037850 Retinoblastoma-binding protein 5/Swd1
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108