PF3D7_0703300

Genome location: Pf3D7_07_v3:128,111..129,083(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.02	0.98
Schizont	no data	0.01	0.99
Gametocyte	no data	0.02	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0703300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.74 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC37

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532378

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	12	3	5
disruptive	2	14	6	31
missense	2	14	5	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	17	3	4
disruptive	7	28	22	39
missense	6	25	19	29

PlasmoDB Total SNPs: 38

Non-coding: 32 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 146 | Molecular Weight (kDa): 17.152

UniProt ID(s): Q8IC37

PDB ID(s): None

Isoelectric Point: 5.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A