PF3D7_0703400

Genome location: Pf3D7_07_v3:129,160..132,186(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	expressed	0.27	0.84
Schizont	possibly expressed	0.07	0.96
Gametocyte	not expressed	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0703400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.756 | MFS: -2.75 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0801100)

Relative Growth Rate: 0.10 ± 0.05
Confidence: 7.56

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8R2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533132

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	48	25	41
disruptive	52	130	78	151
missense	39	118	73	126

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	80	33	60
disruptive	83	285	107	202
missense	61	241	91	156

PlasmoDB Total SNPs: 151

Non-coding: 57 | Synonymous: 46 | Nonsynonymous: 48 | Stop Codon: 0

Protein Information

Protein Length: 820 | Molecular Weight (kDa): 98.263

UniProt ID(s): A0A5K1K8R2

PDB ID(s): None

Isoelectric Point: 9.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A