About Gene List

PF3D7_0703600

Genome location: Pf3D7_07_v3:143,601..146,565(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.04 0.98
Trophozoite not expressed 0.38 0.77
Schizont expressed 1.25 0.42
Gametocyte expressed 0.49 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0703600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.981 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0801300)

  • Relative Growth Rate: 0.70 ± 0.10
  • Confidence: 6.05

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0801300)

Modification: Disrupted | RMgm-2289

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_116284

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 7 6 9
disruptive 5 11 7 20
missense 5 11 7 17

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 13 8 15
disruptive 9 37 11 35
missense 5 27 8 28

PlasmoDB Total SNPs: 303

Non-coding: 290 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 262 | Molecular Weight (kDa): 31.438

UniProt ID(s): None

PDB ID(s): None

Isoelectric Point: 5

Protein Domain Annotations:

Source Family ID Description
InterPro IPR038835 Giardin subunit beta-like
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108