About Gene List

PF3D7_0703800

Genome location: Pf3D7_07_v3:149,804..152,980(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.16 0.92
Trophozoite not expressed 0.11 0.94
Schizont possibly expressed 0.07 0.96
Gametocyte not expressed 0.46 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0703800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.926 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC32

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.61) with 6JWR (Global RMSD=19.47)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125080

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 34 28 51
disruptive 50 125 64 148
missense 32 91 51 118

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 65 32 51
disruptive 91 241 90 201
missense 56 175 71 132

PlasmoDB Total SNPs: 259

Non-coding: 0 | Synonymous: 111 | Nonsynonymous: 148 | Stop Codon: 0

Protein Information

Protein Length: 1058 | Molecular Weight (kDa): 125.008

UniProt ID(s): A0A5K1K890, Q8IC32

PDB ID(s): None

Isoelectric Point: 5.04

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
17653272 Rapid identification of malaria vaccine candidates based on alpha-helical coiledcoil protein motif. Villard V, Agak GW, ..., Corradin G 10.1371/journal.pone.0000645