PF3D7_0703900

Genome location: Pf3D7_07_v3:153,119..167,024(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane
Component	GO:0005634	nucleus
Function	GO:0050699	WW domain binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.44	0.42
Trophozoite	expressed	1.18	0.44
Schizont	expressed	0.44	0.77
Gametocyte	not expressed	1.16	0.44

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0703900

Resistome Missense Mutations: G1758R

Resistome Compounds with Missense Mutations: MMV006901, MMV407834, OSM-S-106

Resistome # Samples with Disruptive Mutations: 18 (17 missense, 17 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.992 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0801600)

Modification: Other | RMgm-468

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532527

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	61	197	124	236
disruptive	249	755	473	949
missense	172	643	427	820

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	95	389	161	322
disruptive	444	1648	646	1223
missense	283	1321	547	868

PlasmoDB Total SNPs: 702

Non-coding: 72 | Synonymous: 294 | Nonsynonymous: 336 | Stop Codon: 0

Protein Information

Protein Length: 4358 | Molecular Weight (kDa): 529.367

UniProt ID(s): A0A143ZY62

PDB ID(s): None

Isoelectric Point: 8.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A