About Gene List

PF3D7_0704000

Genome location: Pf3D7_07_v3:167,240..177,537(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.53 0.75
Trophozoite not expressed 0.72 0.61
Schizont not expressed 0.30 0.82
Gametocyte not expressed 0.66 0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0704000

Resistome Missense Mutations: D2052N

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.475 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533070

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 28 147 91 206
disruptive 191 631 324 747
missense 111 471 261 584

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 53 311 155 226
disruptive 359 1244 532 1025
missense 195 923 417 722

PlasmoDB Total SNPs: 391

Non-coding: 48 | Synonymous: 181 | Nonsynonymous: 162 | Stop Codon: 0

Protein Information

Protein Length: 3268 | Molecular Weight (kDa): 393.465

UniProt ID(s): C0H4K3

PDB ID(s): None

Isoelectric Point: 7.54

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104